Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon

While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of...

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Bibliographic Details
Published in:	Advances in gerontology = Uspekhi gerontologii Vol. 27; no. 1; p. 94
Main Authors:	Mendzheritskiĭ, A M, Karantysh, G V, Ryzhak, G A, Dem'ianenko, S V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2014
Subjects:	Acute Disease Animals Apoptosis - drug effects Brain - drug effects Brain - metabolism Brain - pathology Caspase 3 - metabolism Disease Models, Animal Hypoxia - metabolism Hypoxia - pathology Hypoxia - physiopathology Interleukin-6 - metabolism Male Neurogenesis - drug effects Oligopeptides - pharmacology Peptides - pharmacology Rats Tumor Necrosis Factor-alpha - metabolism
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Summary:	While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level. With the sharp hypoxic hypoxia Cortexin reduces an ability of brain tissue of programmed cells death, but saves the content of interleykin-6 at high level.
ISSN:	1561-9125