MORPHOFUNCTIONAL ADJUSTMENT VASCULAR AND CELLULAR COMPONENTS OF THE CEREBELLAR CORTEX IN EXPOSURE TO BODY SULFATES OF COPPER, ZINC AND IRON

• Published in: Georgian medical news no. 246; p. 84
• Main Authors: Grintsova, N, Vasko, L, Kiptenko, L, Gortinsky, A, Murenets, N
• Format: Journal Article
• Language: Russian
• Published: Georgia (Republic) 01-09-2015
• Subjects: Animals; Cerebellar Cortex - drug effects; Cerebellar Cortex - physiopathology; Copper - toxicity; Humans; Hypoxia - chemically induced; Hypoxia - pathology; Iron - toxicity; Male; Purkinje Cells - drug effects; Purkinje Cells - pathology; Rats; Sulfates - toxicity; Zinc - toxicity
• ISSN: 1512-0112

In order to analyze the morphological and morphometric reconstructions of the vascular bed, and Purkinje cells of the cerebellar cortex of rats in long-term action (for 90 days) on the body of sulphates of copper, zinc and iron, an experiment was conducted on 48 adult white male rats weighing 200-250 g in age 5-7 months. We used anatomical, morphometric, statistical and common methods of microanatomical research. It was found that the combined effect on the body of sulphates of copper and zinc, and iron in the cerebellum has enough expressive toxicity, which affects the condition of the vascular bed, and Purkinje cells. The degree of morphological transformations is in direct proportion to the duration of the experiment. In the pathogenesis of violations leading role played by hypoxia, develop signs of swelling of the cerebellar cortex with signs hemorrhagic infiltration, the severity of which is maximum on the 60th day of the experiment.