Antimycobacterial activity of new N(1)-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives

• Published in: Bioorganic & medicinal chemistry letters Vol. 26; no. 14; pp. 3287 - 3290
• Main Authors: Zampieri, Daniele, Mamolo, Maria Grazia, Vio, Luciano, Romano, Maurizio, Skoko, Nataša, Baralle, Marco, Pau, Valentina, De Logu, Alessandro
• Format: Journal Article
• Language: English
• Published: England 15-07-2016
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antifungal Agents - chemical synthesis; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Bacteria - drug effects; Dose-Response Relationship, Drug; Fungi - drug effects; Imidazoles - chemical synthesis; Imidazoles - chemistry; Imidazoles - pharmacology; Microbial Sensitivity Tests; Molecular Structure; Pyridines - chemical synthesis; Pyridines - chemistry; Pyridines - pharmacology; Structure-Activity Relationship; Mycobacteria other than tuberculosis (MOTT); Antimycobacterial activity; Pyridine-2-carboxamidrazone derivatives
• ISSN: 1464-3405
• DOI: 10.1016/j.bmcl.2016.05.053

N(1)-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives were design, synthesized and tested for their in vitro antimycobacterial activity. The new compounds showed a moderate antimycobacterial activity against the tested strain of Mycobacterium tuberculosis H37Ra and a significant antimycobacterial activity against several mycobacteria other than tuberculosis strains.