Pharmacotherapy of portal hypertension and its complications: analysis of efficacy of preparations for clinical practice and discussion of promising methods of treatment

• Published in: Klinicheskaia meditsina Vol. 91; no. 6; p. 55
• Main Authors: Pavlov, Ch S, Maevskaia, M V, Kitsenko, E A, Kovtun, V V, Ivashkin, V T
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2013
• Subjects: Antihypertensive Agents - classification; Antihypertensive Agents - therapeutic use; Clinical Protocols; Disease Management; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices - diagnosis; Esophageal and Gastric Varices - etiology; Esophageal and Gastric Varices - physiopathology; Esophageal and Gastric Varices - therapy; Gastrointestinal Hemorrhage - etiology; Gastrointestinal Hemorrhage - physiopathology; Gastrointestinal Hemorrhage - prevention & control; Hemostasis, Surgical - methods; Humans; Hypertension, Portal - classification; Hypertension, Portal - etiology; Hypertension, Portal - physiopathology; Hypertension, Portal - therapy; Liver Cirrhosis - complications; Liver Cirrhosis - physiopathology; Outcome Assessment (Health Care); Portal System - drug effects; Portal System - pathology; Portal System - physiopathology; Portasystemic Shunt, Surgical - methods
• ISSN: 0023-2149

Bleeding from oesophageal varicose veins is the terminal stage of a sequence of complications of liver cirrhosis caused by progressive fibrosis, circulation blockade, and development of portal hypertension syndrome followed by collateral shunt. It leads to progressive vein dilation and their rupture. The main issue of today is to prevent the development of successive stages of portal hypertension, to search for therapeutic and surgical methods for marked reduction of pressure in the portal system, and to prevent the risk of hemorrhage from varicose veins. Another approach is to use local endoscopic treatment of varicose veins for prevention of their rupture. The authors analyse the efficacy of pharmacotherapy in patients with liver cirrhosis and portal hypertension and discuss the existing recommendations on the prevention of hemorrhage with special reference to the yet unsolved problems and prospects for the improvement of therapy.