A case of recurrent rectal cancer successfully treated for a long period with capecitabine plus oxaliplatin and bevacizumab therapy

• Published in: Gan to kagaku ryoho Vol. 40; no. 12; p. 2008
• Main Authors: Iwata, Noriko, Ishikawa, Toshiaki, Takahashi, Hidenori, Baba, Hironobu, Masuda, Daiki, Okazaki, Satoshi, Matsuyama, Takatoshi, Ishiguro, Megumi, Kobayashi, Hirotoshi, Iida, Satoru, Uetake, Hiroyuki, Sugihara, Kenichi
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-11-2013
• Subjects: Antibodies, Monoclonal, Humanized - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bevacizumab; Capecitabine; Deoxycytidine - administration & dosage; Deoxycytidine - analogs & derivatives; Female; Fluorouracil - administration & dosage; Fluorouracil - analogs & derivatives; Humans; Middle Aged; Organoplatinum Compounds - administration & dosage; Recurrence; Remission Induction; Sigmoid Neoplasms - drug therapy; Sigmoid Neoplasms - pathology; Sigmoid Neoplasms - surgery; Time Factors
• ISSN: 0385-0684

A 62-year-old woman was diagnosed as having rectal cancer and underwent low anterior resection. The final pathological diagnosis was RS, type 3, circ, mod>muc>por>,pSE, ly1, v1, pN2, sH0, sP0, cM0, fStage IIIb, with KRAS mutation. Adjuvant chemotherapy with tegafur-uracil( UFT) plus Leucovorin( LV) was administered for 6 months. Ten months after surgery, right internal iliac and common iliac lymph node metastasis and peritoneal dissemination were diagnosed. In October 2009, capecitabine plus oxaliplatin (CapeOX) plus bevacizumab (Bmab) therapy was initiated. In May 2010, diagnostic imaging revealed a complete response after 42 months. In the present report, we describe the case of a patient with rectal cancer who experienced postoperative recurrence and achieved long-term complete response with CapeOX plus Bmab therapy. We also include a brief review of the literature.