The expression and clinical significance of Bax and PHF20 in laryngeal squamous cell carcinoma

• Published in: Lin chuang er bi yan hou ke za zhi Vol. 29; no. 19; p. 1701
• Main Authors: Zhang, Chunming, Gao, Wei, Dong, Shubin, Chen, Ganggang, Han, Rui, Wen, Shuxin, Wang, Binquan
• Format: Journal Article
• Language: Chinese
• Published: China 01-10-2015
• Subjects: Antigens, Neoplasm - metabolism; bcl-2-Associated X Protein - metabolism; Biomarkers, Tumor - metabolism; Carcinoma, Squamous Cell - metabolism; Head and Neck Neoplasms - metabolism; Humans; Immunohistochemistry; Laryngeal Neoplasms - metabolism; Lymphatic Metastasis; Prognosis; Squamous Cell Carcinoma of Head and Neck
• ISSN: 1001-1781

To investigate the expression of Bax and PHF20 in laryngeal squamous cell carcinoma (LSCC)and to discuss their relevance and the roles in carcinogenesis and development in LSCC.
The expressions of Bax and PHF20 in the LSCC tissues and normal mucosa tissues adjacent to carcinoma were detected by SP immunohistochemistry assay. The relationship between the expressions of Bax and PHF20 and the clinicopathological characteristics including clinical stage, pathological type, histological grade and lymph node metastasis in LSCC were analyzed according to the clinical data.
(1) The expressions of Bax and PHF20 were both significantly lower in the LSCC tissue than that in the normal laryngeal tissue (P < 0.01). (2) In clinical stage grouping, there were no statistical differences of the quantity and positive rate of Bax and PHF20 expressions among supraglottic, glottic and subglottic LSCC (P > 0.05). In histological differentiation grouping, the quantity and positive rate of Bax and PHF20 expressions decreased signifi