A Useful Method of Nipple-Side HydroMARK-Marking before Neoadjuvant Chemotherapy in the Breast Preserving Surgery-A Case Report with pCR of the Triple Negative Breast Cancer

• Published in: Gan to kagaku ryoho Vol. 48; no. 3; p. 440
• Main Authors: Satoh, Eigo, Uchiyama, Daiki, Uehira, Daisuke, Yonekura, Koji, Murakata, Ayano, Toyofuku, Yasuhiro, Tanami, Hideaki, Osanai, Takayuki, Sugano, Norihide, Sakoma, Takaaki
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-03-2021
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Breast Neoplasms - drug therapy; Breast Neoplasms - surgery; Carcinoma, Ductal, Breast - drug therapy; Carcinoma, Ductal, Breast - surgery; Female; Humans; Middle Aged; Neoadjuvant Therapy; Nipples - surgery; Receptor, ErbB-2; Treatment Outcome; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - surgery
• ISSN: 0385-0684

When the primary breast cancer disappears by neoadjuvant chemotherapy, it is often difficult to detect it during the breast preserving surgery. Before neoadjuvant chemotherapy, preoperative nipple-side HydroMARK-marking, which was made of titanium coil and hydrogel, was a very useful and effective method because of its fine detection by ultrasonography. We report a case of 51-year-old female with the triple negative breast cancer(TNBC). At first, the HydroMARK was inserted between the nipple and the tumor. Its distance was about 10 mm toward the nipple. EC therapy followed by docetaxel was performed for 6 months as neoadjuvant chemotherapy. After that, her left TNBC(T1N0M0, Stage Ⅰ, invasive ductal carcinoma, ER[-], PgR[-], HER2[-])was disappeared in all imagings and resected in August 2018. The HydroMARK was clearly detected by intraoperative ultrasonography and her right breast preserving surgery was completely performed. Its pathological finding was pCR(pathological complete response).