The change of left ventricular function upon acute high altitude exposure and its relationship with acute mountain sickness

• Published in: Zhongguo ying yong sheng li xue za zhi Vol. 30; no. 3; p. 223
• Main Authors: Rao, Ming-Yue, Qin, Jun, Gao, Xu-Bin, Zhang, Ji-Hang, Yu, Jie, Huang, Lan
• Format: Journal Article
• Language: Chinese
• Published: China 01-05-2014
• Subjects: Acute Disease; Adult; Altitude; Altitude Sickness - physiopathology; Humans; Male; Ventricular Function, Left - physiology
• ISSN: 1000-6834

To investigate the changes of the cardiac hemodynamics after acute high altitude exposure in healthy young males and the relationship with acute mountain sickness(AMS).
Left ventricular function and oxyhemoglobin saturation (SaO2), heart rate (HR), blood pressure (BP) were measured in 218 healthy young males before and after high altitude exposure within 24 h respectively. According to the lake louise score criteria, the subjects were divided into two groups: acute mountain sickness group (AMS group) and non acute mountain sickness group (non-AMS group).
HR, diastolic blood pressure (DBP), mean arterial pressure (MAP), left ventricular ejection fraction (LVEF), stroke volume (SV), stroke index (SI) cardiac output (CO), cardiac index (CI) were significantly increased upon acute high altitude exposure (P < 0.05). Whereas SaO2 and end-systolic volume (ESV) were significantly decreased (P < 0.05). In addition, HR, systolic blood pressure (SBP) and MAP in AMS group were significantly higher than those in non-AMS g