Leishmania donovani: structural insignt in the recognition of C-methylated analogues of spermidine as natural polyamine

The ability of alpha-, beta-, gamma- and omega-methylated spermidine analogues to restore the growth of L. donovani promastigotes that were depleted of putrescine and spermidine was investigated. Only beta-methylated spermidine, like natural spermidine was capable of restoring the growth of L. donov...

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Bibliographic Details
Published in:	Molekuliarnaia biologiia Vol. 45; no. 4; p. 673
Main Authors:	Mandal, S, Khomutov, M A, Simonian, A P, Kochetkov, S N, Madhubala, R
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-2011
Subjects:	Biogenic Polyamines - antagonists & inhibitors Biogenic Polyamines - biosynthesis Leishmania donovani - drug effects Leishmania donovani - growth & development Leishmania donovani - metabolism Methylation Spermidine - analogs & derivatives Spermidine - metabolism Spermidine - pharmacology Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology
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Summary:	The ability of alpha-, beta-, gamma- and omega-methylated spermidine analogues to restore the growth of L. donovani promastigotes that were depleted of putrescine and spermidine was investigated. Only beta-methylated spermidine, like natural spermidine was capable of restoring the growth of L. donovani, while the remaining three analogues turned out to be inactive. Considering that alpha-methylated spermidine is a functionally active spermidine surrogate both in vivo and in vitro, this analogue can be considered as an antidote in the host-parasite system, especially in cases where inhibitors of polyamine biosynthesis are used for the therapy of leishmaniasis.
ISSN:	0026-8984