Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats

• Published in: Advances in gerontology = Uspekhi gerontologii Vol. 24; no. 1; p. 74
• Main Authors: Mendzheritskiĭ, A M, Karantysh, G V, Ivonina, K O
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2011
• Subjects: Aging - metabolism; Animals; Behavior, Animal - drug effects; Brain - blood supply; Brain - drug effects; Brain - enzymology; Carotid Stenosis - enzymology; Carotid Stenosis - physiopathology; Carotid Stenosis - prevention & control; Caspase 3 - metabolism; Disease Models, Animal; Injections, Intraperitoneal; Male; Oligopeptides - administration & dosage; Oligopeptides - therapeutic use; Peptides - administration & dosage; Peptides - therapeutic use; Rats; Survival Analysis
• ISSN: 1561-9125

The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted. It is shown that introduction of short peptides promotes a survival rate of the animals that have modeled occlusion of carotid arteries. Under Pinealon before occlusion of carotid arteries, behavioral dream has been increased and a position-finding behavior, a motivational behavior and a motor performance have been reduced. The rats that were introduced Cortexin before carotid arteries occlusion demonstrated the raise of behavioral dream time. At introduction of Pinealon activity of caspase-3 moderately raises in false-operated animals and in a model of occlusion of carotid arteries.