Effect of genistin on proliferative vitreoretinopathy

• Published in: Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 35; no. 7; p. 749
• Main Authors: You, Jiang, Jiang, Deyong
• Format: Journal Article
• Language: Chinese
• Published: China 01-07-2010
• Subjects: Animals; Eye Injuries - complications; Female; Intravitreal Injections; Isoflavones - administration & dosage; Male; Rabbits; Vitreoretinopathy, Proliferative - drug therapy; Vitreoretinopathy, Proliferative - etiology
• ISSN: 1672-7347
• DOI: 10.3969/j.issn.1672-7347.2010.07.017

To examine the effect of genistin on traumatic proliferative vitreoretinopathy (PVR) in rabbits.
Traumatic PVR was induced in pigmented rabbits by intravitreal injection of platelet rich plasma. The eyes then received an intravitreal injection of dimethyl sulfoxide (0.1 mL), 2 or 40 μg genistin (0.1 mL), and 1 mg fluorouracil(0.1 mL), respectively to form 4 groups. The eyes were examined ophthalmoscopically on distinct days after the surgery and the stage of PVR was evaluated. The model eyes and normal eyes in the 40 μg genistin group carried ERG test on the 28th day. All model eyes in the 4 groups were observed by light microscope on the 28th day.
In the control eyes, the retina was detached after 10 d, the PVR had progressed to higher stages with time. In the eyes injected 40 μg genistin or fluorouracil, the PVR also developed; however, the severity of PVR was lower than that in the control eyes. PVR was significantly inhibited in the 40 μg genistin group compared with the control eyes after 14 d (P<0.05).