A case of S-1-resistant gastric cancer with multiple bone metastases and disseminated intravascular coagulation--effective treatment by combined chemotherapy with CDDP and CPT-11

• Published in: Gan to kagaku ryoho Vol. 37; no. 1; p. 165
• Main Authors: Kitagawa, Maki, Oguro, Atsushi, Kondo, Yutaka, Koh, Toshimori, Yamasaki, Junya, Nanri, Masaaki, Nakagawa, Noboru
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-01-2010
• Subjects: Antimetabolites, Antineoplastic - therapeutic use; Antineoplastic Agents - administration & dosage; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bone Neoplasms - secondary; Camptothecin - administration & dosage; Camptothecin - analogs & derivatives; Cisplatin - administration & dosage; Disseminated Intravascular Coagulation - etiology; Drug Combinations; Drug Resistance, Neoplasm; Female; Humans; Middle Aged; Oxonic Acid - therapeutic use; Stomach Neoplasms - complications; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Tegafur - therapeutic use
• ISSN: 0385-0684

A 49-year-old female with advanced gastric cancer complicated with peritoneal dissemination underwent distal gastrectomy, and thereafter she was treated with a combined chemotherapy of S-1 and paclitaxel for 5 months, followed by treatment with S-1 alone. A year after the gastrectomy, she developed disseminated intravascular coagulation (DIC) with multiple bone metastases despite the continuous treatment with S-1, indicating that S-1 was no longer effective. She was then effectively treated by a combined chemotherapy with cisplatin(CDDP)and irinotecan hydrochloride (CPT-11), and DIC subsided within 7 days after the treatment. These findings suggest that combined chemotherapy with CDDP and CPT-11 is a useful regimen for the treatment of certain patients with DIC associated with S-1-resistant advanced gastric cancer.