Predictive value of human fatty acid binding protein for myocardial ischemia and injury in perioperative period of cardiac surgery

• Published in: Zhōnghuá xīnxuèguănbìng zázhì Vol. 38; no. 6; p. 514
• Main Authors: Liu, Yin-he, Zhou, Yi-wen, Tu, Zhi-guang, Ji, Shang-yi, Chen, Man, Huang, Zhi-yong, Yang, Jian-an, Renneberg, R, Wang, Yi, Nie, Zhi-yong, Zhong, An
• Format: Journal Article
• Language: Chinese
• Published: China 01-06-2010
• Subjects: Aged; Albumins - analysis; Biomarkers - blood; Creatine Kinase, MB Form - blood; Fatty Acid-Binding Proteins - blood; Humans; Middle Aged; Myocardial Ischemia - diagnosis; Myocardial Ischemia - surgery; Myocardium - metabolism; Perioperative Period; Predictive Value of Tests; Thoracic Surgery; Troponin I - blood
• ISSN: 0253-3758

To evaluate the value of human fatty acid binding protein (h-FABP) in predicting myocardial ischemia and injury in the perioperative period of cardiac surgery, we observed the dynamic changes of h-FABP in perioperative period of patients underwent coronary artery bypass grafting and ventricular septal defects repairing surgery, and evaluated the relationship of h-FABP and ischemia modified albumin (IMA), CK-MB, cTnI.
Patients underwent coronary artery bypass grafting (n=30) and ventricular septal defect repairing (n=30) surgery between February 2008 and December 2008 were included in this study. Venous blood sample was obtained at preoperative, aortic clamping, aortic unclamping of 10 min, 2 h, 6 h, 12 h, 24 h for the measurements of h-FABP, IMA, cTnI and CK-MB.
h-FABP and IMA changed in the same way at various examined time points, h-FABP changes also paralleled cTnI and CK-MB changes, h-FABP peaked early during myocardial ischemia and injury and returned to baseline level at 2 h post myocardial ischemia and