Effect of propofol-based combined anesthesia on the development of adaptive mechanisms to the prolonged one-lung artificial ventilation

• Published in: Anesteziologiia i reanimatologiia no. 2; p. 4
• Main Authors: Kurilova, O A, Vyzhigina, M A, Sandrikov, V A, Mizikov, V M, Kulagina, T Iu, Zhukova, S G, Parshin, V D
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-03-2010
• Subjects: Adaptation, Physiological; Adolescent; Adult; Aged; Anesthesia, Intravenous - methods; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - adverse effects; Anesthetics, Intravenous - pharmacology; Drug Therapy, Combination; Humans; Infusions, Intravenous; Intubation, Intratracheal; Lung - drug effects; Lung - physiopathology; Lung - surgery; Lung Diseases - surgery; Middle Aged; Propofol - administration & dosage; Propofol - adverse effects; Propofol - pharmacology; Pulmonary Circulation - drug effects; Pulmonary Surgical Procedures - methods; Respiration, Artificial; Respiratory Function Tests; Time Factors; Young Adult
• ISSN: 0201-7563

The paper deals with the assessment of the adequacy and safety of multicomponent anesthesia based on propofol at lung surgery requiring one-lung ventilation (OLV) in patients with chronic respiratory diseases and with the evaluation of the effect of propofol on the development of adaptive mechanisms in various ventilation modalities in thoracic surgery. The pressor, resistive, and volume characteristics of pulmonary blood flow, systemic and intracardiac hemodynamics under artificial ventilation (AV) and OLV of a duration of up to 1.5 hours by a combination of pulmonal and transpulmonal thermodilution on a PiCCO plus device with a VOLEF attachment were compared. Multicomponent balanced anesthesia based on continuous graduated propofol infusion provides adequate protection of patients during thoracic operations, including those with concomitant respiratory abnormality.