Synthesis and anti-inflammatory activity of 2-substituted-((N, N-disubstituted)-1, 3-benzoxazole)-5-carboxamides

A series of 2-substituted-((N, N-disubstituted)-1, 3-benzoxazole)-5-carboxamides derivatives were synthesized by the reaction of 2-substituted-5-carbomethoxy benzoxazole with different secondary amines. The newly synthesized compounds were characterized on the basis of spectral (FT-IR, 1H NMR, MS) &...

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Bibliographic Details
Published in:	Yao hsüeh hsüeh pao Vol. 45; no. 6; p. 730
Main Authors:	Reena, M, Kiran, G, Rajyalakshmi, G, Venkateshwa, Rao J, Sarangapani, M
Format:	Journal Article
Language:	English
Published:	China 01-06-2010
Subjects:	Amides - chemical synthesis Amides - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Benzoxazoles - chemical synthesis Benzoxazoles - pharmacology Carrageenan Edema - chemically induced Edema - drug therapy Male Rats Rats, Wistar
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Summary:	A series of 2-substituted-((N, N-disubstituted)-1, 3-benzoxazole)-5-carboxamides derivatives were synthesized by the reaction of 2-substituted-5-carbomethoxy benzoxazole with different secondary amines. The newly synthesized compounds were characterized on the basis of spectral (FT-IR, 1H NMR, MS) & elemental analysis. All these compounds were screened for anti-inflammatory activity using carrageenan induced rat paw edema method. All of these compounds exhibited significant activity. Among the tested compounds Ve, Vg, Vf and Va were considered to have potent anti-inflammatory activity and was comparable with standard.
ISSN:	0513-4870