Contrasting murine models of MS

There are two main animal model systems currently used to study MS: experimental autoimmune/allergic encephalomyelitis (EAE) and experimental viral infection, including the Theiler's murine encephalomyelitis virus (TMEV). Both models have led to a greater understanding of MS and the development...

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Bibliographic Details
Published in:	International MS journal Vol. 11; no. 3; p. 95
Main Authors:	Nelson, A L A, Bieber, A J, Rodriguez, M
Format:	Journal Article
Language:	English
Published:	England 01-12-2004
Subjects:	Animals Axons - pathology Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - complications Mice Multiple Sclerosis - etiology Multiple Sclerosis - pathology Theilovirus - pathogenicity
Online Access:	Get more information
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Summary:	There are two main animal model systems currently used to study MS: experimental autoimmune/allergic encephalomyelitis (EAE) and experimental viral infection, including the Theiler's murine encephalomyelitis virus (TMEV). Both models have led to a greater understanding of MS and the development of clinical therapies. These systems have allowed in-depth study of the immune system and inflammatory mechanisms potentially involved in MS pathophysiology. Analysing therapeutic successes and failures with both models may also help the development of more directed, positive treatments for MS that have fewer negative effects.
ISSN:	1352-8963