The influence of experimental therapy on the dynamics of endogenous glucosamine content in laboratory animals with nephropathy

• Published in: Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 69; no. 6; p. 40
• Main Authors: Zupanets, I A, Shebeko, S K
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-11-2006
• Subjects: Acetylglucosamine - blood; Animals; Biomarkers - blood; Diclofenac - therapeutic use; Disease Models, Animal; Drug Therapy, Combination; Glomerulonephritis, Membranous - drug therapy; Glucosamine - analogs & derivatives; Glucosamine - therapeutic use; Hexosamines - therapeutic use; Rats
• ISSN: 0869-2092

The effects of glucosamine hydrochloride, glucosamine sulfate, N-acetylglucosamine, glucosamine pentaacetate, and combinations of glucosamine hydrochloride and N-acetylglucosamine with diclofenac sodium on the endogenous glucosamine (aminosugar) content in the blood and kidney of rats with experimental nephropathy have been studied. The development of inflammatory and destructive processes in kidneys is accompanied by an increase in the aminosugar content in the blood serum and the corresponding decrease in renal tissues. This fact can be used as a nonspecific diagnostic criterion for the level of kidney damage and for the efficacy of pharmacotherapy. Normalization of these indices in the case of successful therapy was observed, which was most pronounced upon the administration of glucosamine hydrochloride, N-acetylglucosamine, and their combinations with diclofenac sodium.