A case of advanced gastric cancer with pulmonary carcinomatous lymphangitis responding remarkably to combination chemotherapy of docetaxel, CDDP and S-1

• Published in: Gan to kagaku ryoho Vol. 35; no. 13; p. 2397
• Main Authors: Ishikawa, Takeshi, Oyamada, Hirokazu, Suzuki, Kentaro, Matsuyama, Ryuzo, Isozaki, Yutaka, Okita, Mika, Nagao, Yasuyuki, Kiyota, Keisuke, Kokura, Satoshi, Yoshikawa, Toshikazu
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-12-2008
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cisplatin - therapeutic use; Drug Combinations; Female; Gastroscopy; Humans; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - drug therapy; Lung Neoplasms - secondary; Lymphangitis - diagnostic imaging; Lymphangitis - drug therapy; Lymphangitis - etiology; Lymphangitis - pathology; Neoplasm Staging; Oxonic Acid - therapeutic use; Stomach Neoplasms - complications; Stomach Neoplasms - diagnostic imaging; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Taxoids - therapeutic use; Tegafur - therapeutic use; Tomography, X-Ray Computed; Treatment Failure
• ISSN: 0385-0684

A 31-year-old woman suffering from stomach pain was admitted to our hospital, and diagnosed with unresectable advanced gastric cancer. She was initially treated with combination therapy of S-1 and CDDP, and a partial response was achieved. After two courses of the chemotherapy, however, she complained of dyspnea, and pulmonary carcinomatous lymphangitis was confirmed by computed tomography. As second-line chemo-therapy, we attempted combination therapy with docetaxel, CDDP and S-1(DCS). After one course of the combination therapy, a remarkable response in the pulmonary carcinomatous lymphangitis was achieved. Treatment of patients with advanced gastric cancer associated with pulmonary carcinomatous lymphangitis is quite difficult and there is no scientific evidence to select anti-cancer drugs for these patients. We concluded that DCF could be a useful regimen for patients with gastric cancer associated with pulmonary carcinomatous lymphangitis.