Effect of deltaran on the mediatory balance in the brain of young and old rats with left-side laterality profile in case of carotid arteries occlusion

• Published in: Advances in gerontology = Uspekhi gerontologii Vol. 20; no. 2; p. 138
• Main Authors: Kim, T K, Karantysh, G V, Mendzheritskiĭ, A M, Ryzhak, G A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2007
• Subjects: Aging - metabolism; Aging - pathology; Animals; Arterial Occlusive Diseases - complications; Arterial Occlusive Diseases - metabolism; Arterial Occlusive Diseases - pathology; Brain - blood supply; Brain - drug effects; Brain - metabolism; Brain Ischemia - drug therapy; Brain Ischemia - metabolism; Brain Ischemia - pathology; Brain Ischemia - physiopathology; Carotid Arteries - pathology; Delta Sleep-Inducing Peptide - administration & dosage; Delta Sleep-Inducing Peptide - therapeutic use; Disease Models, Animal; Dopamine - metabolism; Drug Combinations; Functional Laterality; Glycine - administration & dosage; Glycine - therapeutic use; Monoamine Oxidase - metabolism; Neuroprotective Agents - administration & dosage; Neuroprotective Agents - therapeutic use; Rats; Rats, Wistar; Serotonin - metabolism
• ISSN: 1561-9125

The medico-social significance of ischemic brain lesions, which are the most frequent cause of disablement and death in older people, stipulates the need for efficient means of prevention and correction of central nervous system disorders in case of ischemic brain lesions. The efficacy of Deltaran in the correction of disordered neuromediator balance in the brain of rats of different age groups was studied on the model of carotid arteries occlusion. Studies showed, that Deltaran exerts an anti-stress effect on old rats with left-side profile by altering the neuromediators' distribution in animals' brain under conditions of hypoxia. This enables to recommend Deltaran for further study as a neuroprotector.