Influence of genetic and phenotypical factors on the efficiency of the vaccination of young children against diphtheria and measles

The child's sex was shown to influence the character of antibody formation only after immunization against diphtheria with live measles vaccine: girls exhibited stronger reaction to vaccination than boys. Children of different gender were found to have characteristic HLA DR markers of humoral i...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 2; p. 42
Main Authors:	Gordeeva, L A, Shabaldin, A V, Semenova, E M, Glushkov, A N
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-2006
Subjects:	Antibodies, Bacterial - blood Antibodies, Viral - blood Diphtheria - genetics Diphtheria - immunology Diphtheria Toxoid - immunology Diphtheria-Tetanus-Pertussis Vaccine - immunology Female Genotype HLA-DR7 Antigen - immunology Humans Infant Male Measles - genetics Measles - immunology Measles Vaccine - immunology Measles virus - immunology Sex Factors Siberia Vaccination Vaccines, Attenuated - immunology Siberia
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Summary:	The child's sex was shown to influence the character of antibody formation only after immunization against diphtheria with live measles vaccine: girls exhibited stronger reaction to vaccination than boys. Children of different gender were found to have characteristic HLA DR markers of humoral immune response to diphtheria toxoid and measles vaccine. HLA DR7 proved to be the marker of low production of antibodies to diphtheria toxoid and measles vaccine in boys.
ISSN:	0372-9311