Fenugreek seeds modulate 1,2-dimethylhydrazine-induced hepatic oxidative stress during colon carcinogenesis

• Published in: The Italian journal of biochemistry Vol. 56; no. 1; p. 28
• Main Authors: Devasena, T, Venugopal Menon, P
• Format: Journal Article
• Language: English
• Published: Italy 01-03-2007
• Subjects: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents - therapeutic use; Antioxidants - therapeutic use; Catalase - metabolism; Chemical and Drug Induced Liver Injury; Colonic Neoplasms - chemically induced; Colonic Neoplasms - drug therapy; Liver - drug effects; Liver - enzymology; Liver Diseases - drug therapy; Male; Oxidative Stress - drug effects; Phytotherapy; Rats; Rats, Wistar; Seeds; Superoxide Dismutase - metabolism; Trigonella - chemistry
• ISSN: 0021-2938

1,2-dimethylhydrazine (DMH) is a colon carcinogen which undergoes oxidative metabolism in the liver. We have investigated the modulatory effect of fenugreek seeds (a spice) on colon tumor incidence as well as hepatic lipid peroxidation (LPO) and antioxidant status during DMH-induced colon carcinogenesis in male Wistar rats. In DMH treated rats, 100% colon tumor incidence was accompanied by enhanced LPO and a decrease in reduced glutathione (GSH) content as well as a fall in glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) activities. Inclusion of fenugreek seed powder in the diet of DMH treated rats reduced the colon tumor incidence to 16.6%, decreased the LPO and increased the activities of GPx, GST, SOD and CAT in the liver. We report that fenugreek modulates DMH-induced hepatic oxidative stressduring colon cancer