A case of colon cancer with multiple liver, lung and bone metastases successfully treated with combined weekly high-dose 5-FU (WHF) chemotherapy with UFT and CPT-11

• Published in: Gan to kagaku ryoho Vol. 32; no. 10; p. 1481
• Main Authors: Matsuoka, Takahisa, Morikage, Noriyasu, Kobayashi, Tetsuro, Kuga, Takayuki, Nakayama, Tomita, Fujii, Yasuhiro
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-10-2005
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - secondary; Adenocarcinoma - surgery; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bone Neoplasms - secondary; Camptothecin - administration & dosage; Camptothecin - analogs & derivatives; Colectomy; Colonic Neoplasms - drug therapy; Colonic Neoplasms - pathology; Colonic Neoplasms - surgery; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil - administration & dosage; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms - secondary; Lung Neoplasms - secondary; Middle Aged; Tegafur - administration & dosage; Uracil - administration & dosage
• ISSN: 0385-0684

A 54-year-old woman who had ascending colon cancer with multiple liver and lung metastases underwent rt. hemicolectomy and catheter insertion into the gastroduodenal artery for arterial infusion chemotherapy. On postoperative day 7, she had nausea and vomiting due to the enlarged multiple liver metastases on lateral segment. Intraarterial infusion of 5-FU 1,000 mg/m(2) for 5 hours weekly (WHF: weekly high-dose 5-FU) was started at first. After 3 courses, her symptoms improved, oral intake could be started, and liver metastases showed significant reduction on abdominal CT. Three months after surgery, bone scinti revealed multiple bone metastases. Combined HAI (5-FU: 600 mg/m(2)/3 hr) chemotherapy with UFT (400 mg/body) + CPT-11(80/body) and UFT (400 mg/body)/LV (75 mg/body) + CPT-11(100 mg/body) were effective for highly advanced colon cancer in terms of QOL. Eight months after surgery, she was doing well and the chemotherapy was continued. WHF therapy was effective for digestive symptoms due to liver metastasis.