An update on the platelet dysfunction in chronic myeloproliferative syndromes

• Published in: Revue roumaine de médecine interne (1990) Vol. 46; no. 1; pp. 9 - 15
• Main Authors: Vlădăreanu, Ana Maria, Ciufu, Cristina, Bumbea, H, Onisâi, Minodora, Aramă, S
• Format: Journal Article
• Language: English
• Published: Germany 2008
• Subjects: Blood Platelet Disorders - classification; Blood Platelet Disorders - etiology; Blood Platelet Disorders - physiopathology; Blood Platelets - metabolism; Blood Platelets - physiology; Chronic Disease; Hemorrhagic Disorders - blood; Hemorrhagic Disorders - etiology; Hemorrhagic Disorders - physiopathology; Humans; Janus Kinase 2 - genetics; Janus Kinase 2 - metabolism; Janus Kinase 2 - physiology; Myeloproliferative Disorders - blood; Myeloproliferative Disorders - complications; Myeloproliferative Disorders - physiopathology; Platelet Activation - physiology; Receptors, Thrombopoietin - metabolism
• ISSN: 1220-4749

The thrombotic and hemorrhagic diathesis represents a frequent complication in myeloproliferative disorders (CMPD). They are correlated with the number of platelets, but also with their qualitative disorders, such as membrane glycoprotein changes. The latter are revealed by many platelet essays including flow-cytometry and include modified activation, secretion and aggregation patterns. The thrombopoietin platelet receptor (cMPL), affected by the JAK2 V617 mutation encountered in CMPD, may be associated with a prothrombotic status. Its implication reveals the importance of the molecular genetics profile in defining molecular diagnostic hallmarks and makes it a candidate in the early diagnosis of myeloproliferative disorder and a predictor of thrombotic complications in this group of diseases.