A case of extranodal NK/T-cell lymphoma, nasal type, with skin ulceration and multiple nodules in the lung

• Published in: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society Vol. 47; no. 7; p. 614
• Main Authors: Hamaguchi, Reo, Saito, Hiroaki, Kegasawa, Kyoko, Nakagawa, Atsushi, Ryujin, Yasushi, Kurata, Kiyoko, Sugimoto, Hideyasu, Kobayashi, Akiko, Yamazaki, Keiichi, Jin, Yasuto, Yoshimura, Nobuyuki
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-07-2009
• Subjects: Humans; Lung Neoplasms - secondary; Lymphoma, Extranodal NK-T-Cell - pathology; Male; Middle Aged; Multiple Pulmonary Nodules - pathology; Skin Neoplasms - pathology; Skin Ulcer - pathology
• ISSN: 1343-3490

We report a rare case of extranodal NK/T-cell lymphoma, nasal type, with skin ulceration and multiple nodules in the lung, and will compare this case with others in the literature. A 54-year-old man was troubled with flare and swelling of his right arm for one month. He was referred to our hospital because of subcutaneous nodules with ulceration on the right arm, fever, and general fatigue. Chest radiograph revealed multiple nodular shadows in both lungs. The patient was admitted for further evaluation. Chest computed tomography revealed multiple nodules in both lungs with ground-glass opacities around some of them. Some nodules seemed to be clustered in the right lower lobe. Biopsy specimens of subcutaneous nodules and transbronchial biopsy specimens of pulmonary tissue demonstrated only extensive necrosis. A VATS lung biopsy from the right S9 was then taken. Pathological and immunohistological findings suggested a diagnosis of extranodal NK/T-cell lymphoma, nasal type (WHO classification), stage IVB. The patient was transferred to the department of hematology in another hospital for systemic chemotherapy, but died 2 months later.