A successful case of lower gingival cancer with pulmonary metastases by adjuvant chemotherapy including paclitaxel, cisplatin and 5-fluorouracil following a surgical procedure

We report a successful case with pulmonary metastases from lower gingival cancer by a surgical procedure and four cycles of adjuvant chemotherapy including paclitaxel (PTX), cisplatin (CDDP) and 5-fluorouracil (5-FU). A 47-year-old woman underwent chemotherapy with CDDP and 5-FU after an operation f...

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Bibliographic Details
Published in:	Gan to kagaku ryoho Vol. 34; no. 4; p. 597
Main Authors:	Tsukamoto, Goichi, Ibaragi, Soichiro, Shimo, Tsuyoshi, Oyama, Kazuhiko, Kishimoto, Koji, Mese, Hiroshi, Aoe, Motoi, Kiura, Katsuyuki, Sasaki, Akira
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-04-2007
Subjects:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Chemotherapy, Adjuvant Cisplatin - administration & dosage Combined Modality Therapy Drug Administration Schedule Female Fluorouracil - administration & dosage Gingival Neoplasms - drug therapy Gingival Neoplasms - pathology Gingival Neoplasms - surgery Humans Lung Neoplasms - secondary Lung Neoplasms - surgery Lymph Nodes - pathology Lymphatic Metastasis Middle Aged Paclitaxel - administration & dosage Pneumonectomy - methods Remission Induction Thoracic Surgery, Video-Assisted
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Summary:	We report a successful case with pulmonary metastases from lower gingival cancer by a surgical procedure and four cycles of adjuvant chemotherapy including paclitaxel (PTX), cisplatin (CDDP) and 5-fluorouracil (5-FU). A 47-year-old woman underwent chemotherapy with CDDP and 5-FU after an operation for lower gingival squamous cell carcinoma and its neck lymph node metastases. At 4 months from the initial treatment, pulmonary metastatic lesion was resected by video-assisted thoracoscopic surgery (VATS). Fourteen months later, pulmonary metastatic lesion was found and dissected again using VATS. Furthermore, the patient was treated by adjuvant chemotherapy with PTX 135 mg/m(2) over 3 hours on day 1, CDDP 75 mg/m(2)on day 2 and 5-FU 350 mg/m(2)/day by continuous intravenous infusion on day 2 through 5. After that, there is no evidence of pulmonary recurrence for more than six years.
ISSN:	0385-0684