Investigation of inheritance of chronic inflammatory bowel diseases by complex segregation analysis

The mode of inheritance of ulcerative colitis and Crohn's disease was examined by complex segregation analysis. The segregation pattern indicates that a major dominant gene has a role in ulcerative colitis and suggests that a major recessive gene has a role in Crohn's disease.

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Bibliographic Details
Published in:	BMJ. British medical journal (International ed.) Vol. 306; no. 6869; pp. 20 - 24
Main Authors:	ORHOLM, M, ISELIUS, L, SØRENSEN, T. I. A, MUNKHOLM, P, LANGHOLZ, E, BINDER, V
Format:	Journal Article
Language:	English
Published:	London British Medical Association 02-01-1993 BMJ Publishing Group
Edition:	International edition
Subjects:	Biological and medical sciences Colon Digestive system Disease Gastroenterology. Liver. Pancreas. Abdomen Genetics Medical research Medical sciences Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Denmark Europe Human Family study Inheritance Exploration Inflammatory disease Crohn disease Segregation analysis Epidemiologic genetics Digestive diseases Intestinal disease Genetics Molecular biology Anorectal disease Ulcerative colitis
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Summary:	The mode of inheritance of ulcerative colitis and Crohn's disease was examined by complex segregation analysis. The segregation pattern indicates that a major dominant gene has a role in ulcerative colitis and suggests that a major recessive gene has a role in Crohn's disease.
ISSN:	0959-8146