Effect of surface property of different polyether-ester copolymers on growth of smooth muscle cells and endothelial cells

• Published in: Zhongguo xiu fu chong jian wai ke za zhi Vol. 19; no. 6; p. 481
• Main Authors: Chen, Liang, Xi, Tingfei, Yang, Zhiming, Wang, Wei, Liu, Qingyang, Wu, Yingfeng, Gu, Yongquan, Wang, Jiancai, Feng, Zengguo
• Format: Journal Article
• Language: Chinese
• Published: China 01-06-2005
• Subjects: Animals; Biocompatible Materials - chemistry; Cell Proliferation; Cells, Cultured; Dogs; Endothelial Cells - cytology; Endothelium, Vascular - cytology; Ethers - chemistry; Muscle, Smooth, Vascular - cytology; Myocytes, Smooth Muscle - cytology; Polyesters - chemistry; Polymers - chemistry; Surface Properties; Tissue Engineering
• ISSN: 1002-1892

To investigate the effect of surface property of different polyether-ester block copolymers [poly(ethylene glycol-terephthalate)/poly(butylene terephthalate), PEGT/PBT] on the growth of smooth muscle cells (SMCs) and endothelial cells(ECs).
Three kinds of copolymers were synthesized, which were 1000-T20 (group A), 1000PEGT70/PBT30 (group B) and 600PEGT70/PBT30 (group C). The water-uptake and contact angle of three polyether-ester membranes were determined. The canine aorta smooth muscle cells and external jugular vein endothelial cells were primarily harvested, subcultured, and then identified. The proliferation of SMCs and ECs on the different polyether-ester membranes were investigated.
The water-uptake of three copolymers arranged as the sequence of group C<group A<group B, and contact angle as the sequence of group C>group A> group B, indicating group B being more hydrophilic. However, smooth muscle cells and endothelial cells grew poorly on the membrane of group B after low density seeding, but prolifera