Anti-inflammatory drug incorporation into polymeric nano-hybrids for local controlled release

• Published in: International journal of immunopathology and pharmacology Vol. 18; no. 3 Suppl; p. 55
• Main Authors: Sammartino, G, Marenzi, G, Tammaro, L, Bolognese, A, Calignano, A, Costantino, U, Califano, L, Mastrangelo, F, Tetè, S, Vittoria, V
• Format: Journal Article
• Language: English
• Published: England 01-07-2005
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Biomechanical Phenomena; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diclofenac - administration & dosage; Diclofenac - chemistry; Nanocomposites - administration & dosage; Polymers - administration & dosage; Thermogravimetry; X-Ray Diffraction
• ISSN: 0394-6320

In this paper we present the formulation, preparation and characterization of new polymeric composite materials containing a nano-hybrid to be used for the controlled molecular delivery of an anti-inflammatory molecule, Diclofenac. The nano-hybrid consists of a layer of double hydroxide of an Mg-Al hydrotalcite type, in which we replaced the chloride anions present in the host galleries with Diclofenac anions by a simple ion-exchange reaction. Different amounts of the hybrid material were incorporated in polycaprolactone and processed as films of 0.15 mm thickness. The composite materials were analyzed by X-ray diffractometry, thermogravimetry and for their mechanical properties, and showed properties even better than those for the pristine polymer. The release process of the anti-inflammatory molecules was very interesting and promising for tuneable drug delivery. It consists of two stages: a first stage, very rapid as a burst in which a small fraction of the drug is released, and of a second stage that is much slower, extending for longer and longer periods. The parameters influencing the drug release were individuated and discussed.