Antithrombotic therapy for stroke prevention in patients with atrial fibrillation

Atrial fibrillation(AF) is a common arrhythmia that is an important independent risk factor for stroke. The overall risk of stroke in AF patients averages about 5%/y, but with wide variation depending on the presence of coexistent thromboembolic risk factors, which include increasing age, history of...

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Bibliographic Details
Published in:	Nihon rinshō Vol. 58; no. 6; p. 1326
Main Authors:	Tomita, F, Kohya, T, Kitabatake, A
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-06-2000
Subjects:	Age Factors Anticoagulants - administration & dosage Aspirin - therapeutic use Atrial Fibrillation - complications Clinical Trials as Topic Diabetes Complications Humans Hypertension - complications Ischemic Attack, Transient - complications Platelet Aggregation Inhibitors - therapeutic use Risk Factors Stroke - etiology Stroke - prevention & control Thromboembolism - complications Warfarin - administration & dosage
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Summary:	Atrial fibrillation(AF) is a common arrhythmia that is an important independent risk factor for stroke. The overall risk of stroke in AF patients averages about 5%/y, but with wide variation depending on the presence of coexistent thromboembolic risk factors, which include increasing age, history of hypertension, previous stroke or transient ischemic attack(TIA), and diabetes. AF patients with prior stroke or TIA are at highest risk(about 12%/y). Adjusted-dose warfarin(target INR 2.0-3.0) is highly efficacious for preventing stroke in AF patients, and is safe for selected patients. Aspirin has a modest effect on reducing stroke. Warfarin is recommended for high-risk AF patients who can safely receive it. Aspirin may be indicated for those with a low stroke risk and for those who cannot receive warfarin.
ISSN:	0047-1852