Neurotoxicity assessment of selected organic solvents based on spontaneous and evoked cortical and hippocampal activity in rats

• Published in: International journal of occupational medicine and environmental health Vol. 12; no. 1; p. 73
• Main Authors: Tomas, T, Wiaderna, D, Swiercz, R
• Format: Journal Article
• Language: English
• Published: Poland 1999
• Subjects: Animals; Benzene Derivatives - pharmacology; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; Electrodes, Implanted; Electroencephalography; Evoked Potentials - drug effects; Hippocampus - drug effects; Hippocampus - physiology; Male; Motor Activity - drug effects; Rats; Rats, Wistar; Solvents - pharmacology
• ISSN: 1232-1087

In a series of acute experiments on rats the potential of toluene, mesitylene, hemimellitene and pseudocumene to affect the CNS function was assessed following an analysis of spontaneous and evoked hippocampal and cortical activity. The electrophysiological examinations were performed on rats with recording electrodes chronically implanted into selected brain structures. Solvent concentration in peripheral blood was determined by gas chromatography combined with the head space technique in rats with no surgical treatment. The experiments revealed significant quantitative differences between hippocampal and cortical EEG after i.p. injections of equimolar doses of the solvents. A relationship was found between the changes in spontaneous EEG and blood concentration of the solvents. Hemimellitene, with the lowest recorded blood level was found to have the highest potential for inducing the CNS effects.