Weekly low-dose CPT-11 and HCFU for advanced colorectal cancer on an outpatient treatment basis

• Published in: Gan to kagaku ryoho Vol. 27; no. 6; p. 915
• Main Authors: Sasaki, K, Takasaka, H, Kawasaki, H, Matsunaga, T, Nakagawa, N, Shibata, K, Yabana, T, Yasojima, T, Furuhata, T, Hata, F, Hirata, K
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-06-2000
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - secondary; Adenocarcinoma - surgery; Administration, Oral; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Camptothecin - administration & dosage; Camptothecin - analogs & derivatives; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Drug Administration Schedule; Female; Fluorouracil - administration & dosage; Fluorouracil - analogs & derivatives; Humans; Infusions, Intravenous; Lymph Node Excision; Lymphatic Metastasis
• ISSN: 0385-0684

We attempted a new outpatient treatment using weekly low-dose CPT-11 for advanced colorectal cancer patients. A 73-year-old female with para-aortic lymph node metastases from advanced rectal cancer was given outpatient treatment for more than 5 months with weekly low-dose CPT-11 and HCFU. CPT-11 was given intravenously at a dose of 20 mg/m2 on day 1 every week. On days 2-7, she was treated by oral administration of HCFU (600 mg). Her serum CEA level decreased and continued to do so for more than 5 months. The size of the para-aortic lymph node was reduced by approximately 40%. There were no adverse effects except leukopenia (grade 2). These results suggest that weekly low-dose CPT-11 and oral HCFU may be an effective therapy on an outpatient basis in cases of advanced colorectal cancer.