Effect of whole body gamma radiation on hepatic LDH activity, lactate, pyruvate concentration and rate of oxygen consumption in Bufo melanostictus

Whole body Co60 gamma radiation induced changes in lactic dehydrogenase (LDH) activity, pyruvate, lactate content and rate of oxygen (O2) consumption in a tropical hibernating anuran (Bufo melanostictus). In 3.5 and 7 Gy treated groups, a significant increase in LDH activity and lactate/pyruvate rat...

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Bibliographic Details
Published in:	Indian journal of experimental biology Vol. 40; no. 11; p. 1310
Main Authors:	Mishra, J, Mittra, B, Mittra, A
Format:	Journal Article
Language:	English
Published:	India 01-11-2002
Subjects:	Animals Bufonidae Dose-Response Relationship, Radiation Gamma Rays - adverse effects L-Lactate Dehydrogenase - metabolism Lactic Acid - metabolism Liver - enzymology Liver - radiation effects Oxygen Consumption - radiation effects Pyruvic Acid - metabolism Whole-Body Irradiation
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Summary:	Whole body Co60 gamma radiation induced changes in lactic dehydrogenase (LDH) activity, pyruvate, lactate content and rate of oxygen (O2) consumption in a tropical hibernating anuran (Bufo melanostictus). In 3.5 and 7 Gy treated groups, a significant increase in LDH activity and lactate/pyruvate ratio was observed, whereas a significant decrease in O2 consumption rate was observed in treated animals on post-irradiation day (PID) 1, 5 and 10. Increase in LDH activity was observed on PID-1 in both the treated groups, reached to a peak on PID-5 in 7 Gy treated group and then declined on PID-10.
ISSN:	0019-5189