Use of N-acetylcysteine in the management of coronary artery diseases

Thrombolysis after acute myocardial infarction may lead to a number of adverse effects (reperfusion injury) such as myocardial stunning, arrhythmias and even myocardial damage and extension of the infarct size. Some recent clinical studies have demonstrated that the intravenous infusion of N-acetylc...

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Bibliographic Details
Published in:	Cardiologia (Rome, Italy) Vol. 44; no. 7; p. 633
Main Authors:	Marchetti, G, Lodola, E, Licciardello, L, Colombo, A
Format:	Journal Article
Language:	English
Published:	Italy 01-07-1999
Subjects:	Acetylcysteine - adverse effects Acetylcysteine - therapeutic use Angina, Unstable - drug therapy Animals Clinical Trials as Topic Coronary Disease - drug therapy Drug Evaluation, Preclinical Drug Therapy, Combination Free Radical Scavengers - adverse effects Free Radical Scavengers - therapeutic use Humans Nitroglycerin - therapeutic use Vasodilator Agents - therapeutic use
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Summary:	Thrombolysis after acute myocardial infarction may lead to a number of adverse effects (reperfusion injury) such as myocardial stunning, arrhythmias and even myocardial damage and extension of the infarct size. Some recent clinical studies have demonstrated that the intravenous infusion of N-acetylcysteine during thrombolysis was associated with a decrease in infarct size and better preservation of left ventricular function, probably due to antioxidant and free radical scavenger properties of N-acetylcysteine. Short- and long-term studies indicated that also in patients with unstable angina pectoris and threat of infarct, the intravenous or oral administration of N-acetylcysteine in association with nitroglycerin is highly effective in decreasing the risk of worsening, mainly by preventing the occurrence of acute myocardial infarction.
ISSN:	0393-1978