Potentiation of acetylcholine-induced smooth muscle contraction in rat ileum by lead

The aim of this study was to find out lead interaction on acetylcholine-induced ileal (0.8 "to 1" longitudinal total strips) contractions in varying calcium (Ca++) or magnesium (Mg++) media and the cholinergic mechanism. Potentiation of ileal strips by lead (Pb++) remained dose-dependent a...

Full description

Saved in:

Bibliographic Details
Published in:	Annals of the Academy of Medicine, Singapore Vol. 28; no. 4; p. 488
Main Authors:	Gandhi, D N, Venkatakrishna-Bhatt, H
Format:	Journal Article
Language:	English
Published:	Singapore 01-07-1999
Subjects:	Acetylcholine - pharmacology Animals Atropine - pharmacology Dose-Response Relationship, Drug Drug Synergism Female Ileum - drug effects Ileum - physiology In Vitro Techniques Lead - pharmacology Magnesium - pharmacology Male Muscarinic Antagonists - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Rats Rats, Wistar
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The aim of this study was to find out lead interaction on acetylcholine-induced ileal (0.8 "to 1" longitudinal total strips) contractions in varying calcium (Ca++) or magnesium (Mg++) media and the cholinergic mechanism. Potentiation of ileal strips by lead (Pb++) remained dose-dependent as elicited by acetylcholine-induced contractions (1.81 x 10(-6) M to 1.28 x 10(-4) M). These were completely antagonized by atropine (1.01 x 10(-8) M). Lead (1.2 x 10(-5) M) potentiated contractions caused by acetylcholine in normal or in excess Ca++ media, but in low Ca++ or with various Mg++ media, lead failed to potentiate such contractions. Thus Pb++ has indirect cholinomimetic effect which involved extracellular Ca++.
ISSN:	0304-4602