A case of recurrent lung cancer successfully treated with vinorelbine and cisplatin/carboplatin

• Published in: Gan to kagaku ryoho Vol. 30; no. 7; p. 981
• Main Authors: Suzuki, Hiroyuki, Shirane, Kenji, Nasu, Hiroshi, Muto, Osamu, Nakagawa, Taku, Ogawa, Jun-ichi
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-07-2003
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - surgery; Aged; Alopecia - chemically induced; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Carboplatin - administration & dosage; Cisplatin - administration & dosage; Combined Modality Therapy; Drug Administration Schedule; Humans; Lung Neoplasms - drug therapy; Lung Neoplasms - surgery; Lymph Node Excision; Male; Nausea - chemically induced; Neoplasm Recurrence, Local - drug therapy; Neutropenia - chemically induced; Pneumonectomy; Remission Induction; Vinblastine - administration & dosage; Vinblastine - analogs & derivatives; Vomiting, Anticipatory - etiology
• ISSN: 0385-0684

A 73-year-old male underwent lobectomy with ND2a lymph node dissection and resection of the superior vena cava for right lung cancer in December 1998 at Akita University Hospital. Histopathological examination demonstrated moderately differentiated adenocarcinoma (pT4 (SVC) N2M0, Stage IIIB). He received 1 course of a combination of cisplatin (CDDP) and etoposide (ETP) as postoperative adjuvant therapy. In March 2001, he again underwent partial resection of the right lung (S8) due to recurrence. In December 2001, a new left lung metastatic tumor was found. The patient was transferred to our hospital, where he was given 1 course of vinorelbine (NVB) 25 mg/m2 (day 1, 8) and CDDP 80 mg/m2 (day 1). Subsequently, he received 2 courses of vinorelbine (NVB) 25 mg/m2 (day 1, 8) and carboplatin (CBDCA) 430 mg/body (day 1). After the chemotherapy, a complete response (CR) of metastatic lesions was achieved. Adverse reactions were grade 3 neutropenia, grade 2 alopecia and grade 1 nausea/vomiting. The combination of vinorelbine and platinum agent (CDDP/CBDCA) is a useful regimen in treating recurrent non-small-cell lung cancer.