Characteristics and clinical value of extended-spectrum beta-lactamases

The literature data and the findings of the authors' studies on the role of extended-spectrum bata-lactamases (ESBL) in providing the clinical effect in the treatment of infections due to ESBL-producing organisms were analyzed. The analysis allowed to consider the NCCLS recommendations not suff...

Full description

Saved in:

Bibliographic Details
Published in:	Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 48; no. 7; p. 5
Main Authors:	Berezin, A G, Romashov, O M, Iakovlev, S V, Sidorenko, S V
Format:	Journal Article
Language:	English Russian
Published:	Russia (Federation) 2003
Subjects:	Adolescent Adult Aged Animals Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - therapeutic use Aztreonam - metabolism Aztreonam - therapeutic use beta-Lactam Resistance beta-Lactamases - metabolism Cephalosporins - metabolism Cephalosporins - therapeutic use Community Health Centers Enterobacteriaceae - drug effects Enterobacteriaceae - enzymology Enterobacteriaceae - pathogenicity Enterobacteriaceae Infections - drug therapy Escherichia coli - drug effects Escherichia coli - enzymology Humans Klebsiella - drug effects Klebsiella - enzymology Middle Aged Penicillins - metabolism Penicillins - therapeutic use Russia Russia
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The literature data and the findings of the authors' studies on the role of extended-spectrum bata-lactamases (ESBL) in providing the clinical effect in the treatment of infections due to ESBL-producing organisms were analyzed. The analysis allowed to consider the NCCLS recommendations not sufficiently valid. According to these recommendations the ESBL-producing organisms (among E. coli and Klebsiella spp.) should be regarded as resistant to penicillins, cephalosporins and aztreonam. Susceptibility of 62 Enterobacteriaceae strains that were isolated in 4 therapeutic centres of Tomsk, Nazran and Moscow and proved to be ESBL-producing organisms was tested and it was shown that the 3rd and 4th generation cephalosporins could not be referred to a homogenous group. The same was confirmed by the prospective and retrospective investigations of a multiprofile hospital on the clinical and bacteriological efficacies of the 3rd generation cephalosporins and cefepime in the treatment of hospital-acquired infections due to Enterobacteriaceae strains producing ESBL.
ISSN:	0235-2990