Effect of lipiodol-cisplatinum arterial infusion chemotherapy on cellular immunity

A Lipiodol-cisplatinum suspension (LPD/CDDP) was applied by intrahepatic arterial infusion chemotherapy to treat 15 cases of inoperable hepatoma. Pre- and post-application changes in leucocytes, monocytes, platelets and lymphocytes in patients were examined. Natural killer activity was determined an...

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Bibliographic Details
Published in:	Gan to kagaku ryoho Vol. 19; no. 3; p. 327
Main Authors:	Ohsumi, M, Koitabashi, H, Nagamachi, Y, Iijima, T
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-03-1992
Subjects:	Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - immunology Cisplatin - administration & dosage Hepatic Artery Humans Immunity, Cellular Infusions, Intra-Arterial Iodized Oil - administration & dosage Killer Cells, Natural - immunology Liver Neoplasms - drug therapy Liver Neoplasms - immunology Methylprednisolone - administration & dosage Middle Aged T-Lymphocyte Subsets
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Summary:	A Lipiodol-cisplatinum suspension (LPD/CDDP) was applied by intrahepatic arterial infusion chemotherapy to treat 15 cases of inoperable hepatoma. Pre- and post-application changes in leucocytes, monocytes, platelets and lymphocytes in patients were examined. Natural killer activity was determined and analysis by two-color method was performed. After infusion chemotherapy, leucocytosis and monocytosis were quite conspicuous. NK activity was reduced after application of LPD/CDDP, but this effect may have been partly due to the influence of methylprednisolone. Cellular immunity was not influenced by LPD/CDDP infusion without low reduction of NK activity.
ISSN:	0385-0684