A case of melorheostosis with linear sclerodermatous skin changes

• Published in: Ryumachi. [Rheumatism] Vol. 35; no. 3; p. 580
• Main Authors: Takeda, T, Ogura, N, Jodo, S, Amasaki, Y, Nakabayashi, T, Ichikawa, K, Tsutsumi, A, Ohnishi, K, Fujisaku, A, Kobayashi, S
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-06-1995
• Subjects: Aged; Diagnosis, Differential; Female; Humans; Melorheostosis - diagnosis; Melorheostosis - diagnostic imaging; Muscle, Skeletal - pathology; Radiography; Scleroderma, Localized - diagnosis; Skin - pathology
• ISSN: 0300-9157

A 69-years old Japanese woman complained of pain in the left elbow joint and thickened skin over the left upper limb. The pain had been present for 20 years, and the thickened area of the skin gradually enlarged during this period. Her left elbow joint showed some limitation of motion. There was no record of any similar condition in her family history. Radiographs of the left limb showed cortical hyperostosis extending from the middle of the left humerus to the distal end of the radius. Radiographs of the other limbs were normal. A technetium 99m-methylene diphosphonate bone scintigraphy revealed increased uptake in the areas of radiographic hyperostosis. The diagnosis of melorheostosis was made. Skin biopsy of thickened area was performed. The epidermis was normal, and proliferation of normal-appearing collagen fibers into the subcutaneous fat was noted. No inflammatory changes were found. The cause of sclerodermatous skin changes was thought to be not by linear scleroderma but by melorheostosis. In cases of linear sclerodermatous changes, melorheostosis as its origin should be considered.