The effect of TPP, theophylline and theobromine on the angiogenic activity of mononuclear leucocytes obtained from diabetic patients with proliferative retinopathy

Tołpa Peat Preparation (TPP) administered in various doses does not influence the ability of mononuclear cells (MNC) obtained from diabetic patients with proliferative retinopathy to induce neovascularization response in H-LIA test. Methylxanthines (theophylline, theobromine) significantly decrease...

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Bibliographic Details
Published in:	Acta Poloniae pharmaceutica Vol. 50; no. 4-5; p. 409
Main Authors:	Skopiński, P, Zukowska, M, Małkowska-Zwierz, W, Radomska, D, Retelska, D, Kecik, D, Domosławski, M, Sobczyńska, A, Pawińska, M, Skopińska-Rózewska, E
Format:	Journal Article
Language:	English
Published:	Poland 1993
Subjects:	Adolescent Adult Amino Acids - pharmacology Animals Carbohydrates - pharmacology Child Diabetic Retinopathy - pathology Drug Combinations Humans Humic Substances - pharmacology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - physiology Mice Mice, Inbred BALB C Neovascularization, Pathologic - etiology Soil Theobromine - pharmacology Theophylline - pharmacology Uronic Acids - pharmacology
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Summary:	Tołpa Peat Preparation (TPP) administered in various doses does not influence the ability of mononuclear cells (MNC) obtained from diabetic patients with proliferative retinopathy to induce neovascularization response in H-LIA test. Methylxanthines (theophylline, theobromine) significantly decrease the angiogenic activity of these cells. The therapeutic value of these drugs in proliferative retinopathy should be evaluated.
ISSN:	0001-6837