Mathematical model of antiviral immune response regulation. I. Conceptual description of the modelled processes

The report covers the initial steps in construction of a mathematical model, namely a conceptual description of antiviral immune response regulation. The model describes cellular and molecular levels of the basic mechanisms: interaction of virus with a sensitive cell; action and activation of nonspe...

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Bibliographic Details
Published in:	Folia biologica Vol. 37; no. 1; p. 1
Main Authors:	Chuykov, V V, Bazhan, S I, Kulichov, V A
Format:	Journal Article
Language:	English
Published:	Czech Republic 1991
Subjects:	Antibody Formation Cell Cycle Immunity, Cellular Interferons - biosynthesis Interleukin-1 - biosynthesis Interleukin-2 - biosynthesis Lymphocyte Cooperation Models, Biological T-Lymphocyte Subsets - immunology T-Lymphocytes, Helper-Inducer - immunology Virus Diseases - immunology
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Summary:	The report covers the initial steps in construction of a mathematical model, namely a conceptual description of antiviral immune response regulation. The model describes cellular and molecular levels of the basic mechanisms: interaction of virus with a sensitive cell; action and activation of nonspecific resistance factors (phagocytosis, antiviral action of interferon, humoral inhibitors, and natural killer cells in the course of the immune response; humoral and cellular immune response induction and the specific antiviral defence mechanisms. Two helper cell subpopulations are considered explicitly: cellular immune response T helper cells, also named inflammatory cells (TH1) and humoral immune response T helper cells (TH2). Regulation of interleukin 1-, 2- and 4-induced lymphocyte progression through cell cycle phases is described.
ISSN:	0015-5500