Biologically ineffective gonadotropin secretion: two cases

Symptoms of gonadal insufficiency, in the presence of high serum levels of gonadotropins, generally indicate primary gonadal failure. An exception to this generalization is the secretion of ineffective gonadotropic hormone secretion by the pituitary. One such case was reported in 1979. However rare...

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Bibliographic Details
Published in:	Endocrinologie Vol. 26; no. 1; p. 55
Main Authors:	Koloğlu, S, Uysal, A R, Koloğlu, L B
Format:	Journal Article
Language:	English
Published:	Romania 01-01-1988
Subjects:	Adolescent Adult Cryptorchidism - blood Diagnosis, Differential Follicle Stimulating Hormone - blood Gonadotropins, Pituitary - physiology Humans Hypogonadism - blood Hypogonadism - diagnosis Hypogonadism - drug therapy Luteinizing Hormone - blood Male Puberty, Delayed - blood Puberty, Delayed - diagnosis Sperm Count Testosterone - blood
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Summary:	Symptoms of gonadal insufficiency, in the presence of high serum levels of gonadotropins, generally indicate primary gonadal failure. An exception to this generalization is the secretion of ineffective gonadotropic hormone secretion by the pituitary. One such case was reported in 1979. However rare it may be, this disorder should still be taken into consideration when evaluating hypogonadal patients. In fact, it may not be so rare as it is supposed. In this report, two such cases are presented. They both show signs of gonadal insufficiency in the presence of high serum gonadotropin concentrations, but responding normally to exogenously administered chorionic gonadotropin.
ISSN:	0253-1801