Demonstration of PIVKA-II and AFP production by gastric cancer by indirect immunoenzymatic staining of paraffin sections

The patient had elevated plasma PIVKA-II and serum AFP levels. However, no tumor was detected with an ultrasonography, angiography, abdominal computed tomography (CT), and magnetic resonance imaging (MR). Gastric endoscopic examination disclosed gastric cancer and then subtotal gastrectomy was done....

Full description

Saved in:

Bibliographic Details
Published in:	Rinsho byori. The Japanese journal of clinical pathology Vol. 39; no. 6; p. 605
Main Authors:	Nakamura, K, Sakizono, K, Oita, T, Kudo, M, Shirane, H, Uchida, H, Kasakura, S
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-06-1991
Subjects:	alpha-Fetoproteins - biosynthesis Biomarkers Biomarkers, Tumor - biosynthesis Humans Immunoenzyme Techniques Male Middle Aged Protein Precursors - biosynthesis Prothrombin - biosynthesis Staining and Labeling Stomach Neoplasms - metabolism
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The patient had elevated plasma PIVKA-II and serum AFP levels. However, no tumor was detected with an ultrasonography, angiography, abdominal computed tomography (CT), and magnetic resonance imaging (MR). Gastric endoscopic examination disclosed gastric cancer and then subtotal gastrectomy was done. Shortly after the surgery, both plasma PIVKA-II and serum AFP levels returned to each normal level. The extirpated tumor revealed histologically immature and mature cancer cells. It was pathologically diagnosed as IIc early cancer. The localization of PIVKA-II and AFP in gastric cancer cells was demonstrated by the immunostaining method using monoclonal antibody. Taken together, these results indicate that cancer cells may produce PIVKA-II or AFP in this patient.
ISSN:	0047-1860