Depletion of phenylalanine in the blood of phenylketonuric patients using a PAL-enzyme reactor. An in vitro study

Blood samples obtained from eight adult phenylketonuric individuals had a mean phenylalanine level of 25 mg/dl. When these samples were circulated through multitubular enzyme-reactors prepared with immobilized phenylalanine ammonia lyase an average of 77% of phenylalanine was metabolized within 30 m...

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Bibliographic Details
Published in:	Research communications in chemical pathology and pharmacology Vol. 37; no. 1; p. 105
Main Authors:	Ambrus, C M, Horváth, C, Kalghatgi, K, Clowsley, M, Huzella, C, Warner, R, Ambrus, J L, Cooley, C M, Mirand, E A
Format:	Journal Article
Language:	English
Published:	United States 01-07-1982
Subjects:	Adult Ammonia-Lyases - therapeutic use Enzymes, Immobilized - therapeutic use Humans Phenylalanine - blood Phenylalanine Ammonia-Lyase - therapeutic use Phenylketonurias - blood Phenylketonurias - therapy Time Factors
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Summary:	Blood samples obtained from eight adult phenylketonuric individuals had a mean phenylalanine level of 25 mg/dl. When these samples were circulated through multitubular enzyme-reactors prepared with immobilized phenylalanine ammonia lyase an average of 77% of phenylalanine was metabolized within 30 minutes. We conclude that phenylalanine in human phenylketonuric blood is just as susceptible to metabolism by PAL-enzyme reactors as phenylalanine that is added to normal blood, or that is circulating in dogs and monkeys made hyperphenylalaninemic by experimental means.
ISSN:	0034-5164