Immunological problems of polymer-bound drugs

• Published in: Critical reviews in therapeutic drug carrier systems Vol. 1; no. 4; p. 311
• Main Authors: Rihova, B, Riha, I
• Format: Journal Article
• Language: English
• Published: United States 1985
• Subjects: Amino Acids - immunology; Animals; Antibody Formation - drug effects; Antigens - immunology; B-Lymphocytes - immunology; Complement System Proteins - immunology; Dextrans - immunology; Excipients; Humans; Immunity - drug effects; Immunity, Cellular - drug effects; Immunoglobulins - immunology; Lymphatic System - immunology; Lymphokines - pharmacology; Macrophages - immunology; Molecular Conformation; Molecular Weight; Monocytes - immunology; Pharmaceutical Preparations - administration & dosage; Plasma Substitutes - pharmacology; Polymers; Species Specificity; T-Lymphocytes - immunology; Vaccines - immunology
• ISSN: 0743-4863

For the application of polymer-bound drugs (especially in combination with the targeting antibodies), it is essential to know more about the immunogenicity and possible hazards from immune reactions induced by their repeated application. The immune reaction depends on many factors (including structure of antigen, dose of antigen, schedule and way of the application, genetic background of the immunized, i.e., receiving organism) and could be weakened or eliminated by a choice of suitable factors. Problems connected with the immune reaction of the humoral and cellular type (B and T cell involvement) against different polymers and polymer-bound drugs and possible consequences for their clinical use will be discussed.