Opposing effects of filariasis and chronic malaria on immunoregulatory T lymphocytes

The effect of parasitic infections on immunoregulatory T lymphocytes was evaluated by means of quantitative determinations of total T cell and T-cell subset populations present in peripheral blood of patients with lymphatic filariasis, with the malaria-induced tropical splenomegaly syndrome (TSS), a...

Full description

Saved in:

Bibliographic Details
Published in:	Diagnostic immunology Vol. 1; no. 3; p. 257
Main Authors:	Piessens, W F, Hoffman, S L, Ratiwayanto, S, Piessens, P W, Partono, F, Kurniawan, L, Marwoto, H A
Format:	Journal Article
Language:	English
Published:	United States 1983
Subjects:	Adult Brugia Chronic Disease Filariasis - immunology Humans Leukocyte Count Malaria - immunology Phenotype Splenomegaly - immunology Syndrome T-Lymphocytes - classification T-Lymphocytes - immunology Tropical Climate Wuchereria bancrofti
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The effect of parasitic infections on immunoregulatory T lymphocytes was evaluated by means of quantitative determinations of total T cell and T-cell subset populations present in peripheral blood of patients with lymphatic filariasis, with the malaria-induced tropical splenomegaly syndrome (TSS), and with both infections. Total T-cell numbers were similar to control values in patients without TSS, and reduced in donors with TSS. OKT4+/OKT8+ T-cell ratios were decreased in microfilaremic donors without TSS (0.76 +/- 0.08) and elevated in patients with TSS without microfilaremia (1.97 +/- 0.16). Patients with dual infections tended to yield results similar to uninfected control donors. Thus, filariasis and chronic malaria (TSS) have opposing effects on the normal balance of immunoregulatory T lymphocytes. In patients with TSS, the imbalance appears to result from a decrease in the absolute number of circulating T cells with suppressor/cytotoxic phenotype.
ISSN:	0735-3111