Chronic neutropenia: possible association with Sjögren's syndrome

Three white males, ages 42-59, with chronic neutropenia are described. All 3 patients had splenomegaly, positive tests for rheumatoid factor, elevated erythrocyte sedimentation rates, hypergammaglobulinemia and bone marrow examinations which showed normal to increased cellularity. Two of the 3 patie...

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Bibliographic Details
Published in:	Journal of rheumatology Vol. 8; no. 4; p. 679
Main Authors:	Starkebaum, G, Dancey, J T, Arend, W P
Format:	Journal Article
Language:	English
Published:	Canada 01-07-1981
Subjects:	Adult Agranulocytosis - complications Antilymphocyte Serum - analysis Chronic Disease Humans Immunoglobulin G - analysis Kinetics Male Middle Aged Neutropenia - blood Neutropenia - complications Neutrophils - physiology Sjogren's Syndrome - complications
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Summary:	Three white males, ages 42-59, with chronic neutropenia are described. All 3 patients had splenomegaly, positive tests for rheumatoid factor, elevated erythrocyte sedimentation rates, hypergammaglobulinemia and bone marrow examinations which showed normal to increased cellularity. Two of the 3 patients had recurring arthralgias and positive tests for antinuclear antibodies. All 3 patients had evidence for decreased tearing suggestive of Sjogren's syndrome, but in only 1 patient was a positive lip biopsy obtained. One patient had repeated cutaneous infections which ceased after splenectomy resulted in an increased neutrophil count. Serum IgG neutrophil-binding and in vivo neutrophil kinetic studies on 1 patient were consistent with a humoral immune mechanism for his neutropenia.
ISSN:	0315-162X