Dopaminergic control of adenohypophyseal growth

The chronic administration of large doses of oestrogens to rats results in an increase in the weight of the adenohypophysis, in the thyroxine-binding capacity of the adenohypophyseal proteins and in the serum ceruloplasmin level. Testosterone, ant-oestrogens and an excess dose of the thyroid hormone...

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Bibliographic Details
Published in:	Voprosy biokhimii mozga Vol. 13; p. 221
Main Author:	Schreiber, V
Format:	Journal Article
Language:	English
Published:	Armenia (Republic) 1978
Subjects:	Animals Catechol O-Methyltransferase Inhibitors Ceruloplasmin - analysis Dopamine - physiology Drug Interactions Estrogens - pharmacology Perphenazine - pharmacology Pimozide - pharmacology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - growth & development Pituitary Gland, Anterior - metabolism Rats Thyroxine - metabolism
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Summary:	The chronic administration of large doses of oestrogens to rats results in an increase in the weight of the adenohypophysis, in the thyroxine-binding capacity of the adenohypophyseal proteins and in the serum ceruloplasmin level. Testosterone, ant-oestrogens and an excess dose of the thyroid hormones cause parallel inhibition of all three reactions. The dopaminergic neuron blocker Pimozide potentiates all three reactions, while perphenazine, in the tested doses potentiated only the adenohypophyseal reactions. In the tested doses, dopaminergic neuron stimulators (ergocornine and analogous substances) inhibited only the adenohypophyseal reactions. The nature of the relationships between the three reactions in question is considered.
ISSN:	0507-2972