Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Casablanca cohort of the A1chieve study

• Published in: Indian journal of endocrinology and metabolism Vol. 17; no. Suppl 2; pp. S408 - S412
• Main Authors: Farouqi, Ahmed, Chadli, Asmae
• Format: Journal Article
• Language: English
• Published: India Medknow Publications & Media Pvt Ltd 01-11-2013
• Subjects: Original; type 2 diabetes mellitus; A1chieve study; insulin analogues; Casablanca
• ISSN: 2230-8210; 2230-9500
• DOI: 10.4103/2230-8210.122042

The A1chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents.
Data was collected at baseline, at 12 weeks and at 24 weeks. This short communication presents the results for patients enrolled from Casablanca, Morocco.
A total of 495 patients were enrolled in the study. Four different insulin analogue regimens were used in the study. Study patients had started on or were switched to biphasic insulin aspart (n = 231), insulin detemir (n = 151), insulin aspart (n = 19), basal insulin plus insulin aspart (n = 53) and other insulin combinations (n = 41). At baseline glycaemic control was poor for both insulin naïve (mean HbA1c: 10.2%) and insulin user (mean HbA1c: 9.4%) groups. After 24 weeks of treatment, both groups showed improvement in HbA1c (insulin naïve: -2.3%, insulin users: -1.8%). Major hypoglycaemia was observed in the insulin naïve group after 24 weeks. SADRs were reported in 1.2% of insulin naïve and 2.1% of insulin user groups.
Starting or switching to insulin analogues was associated with improvement in glycaemic control with a low rate of hypoglycaemia.