Comparative Analysis of the Antineoplastic Activity of C 60 Fullerene with 5-Fluorouracil and Pyrrole Derivative In Vivo

• Published in: Nanoscale research letters Vol. 12; no. 1; p. 8
• Main Authors: Lynchak, O V, Prylutskyy, Yu I, Rybalchenko, V K, Kyzyma, O A, Soloviov, D, Kostjukov, V V, Evstigneev, M P, Ritter, U, Scharff, P
• Format: Journal Article
• Language: English
• Published: United States 01-12-2017
• Subjects: 5-Fluorouracil; C60 fullerene; Pyrrole derivative; Molecular modeling; Colorectal cancer; Small-angle X-ray scattering
• ISSN: 1931-7573
• DOI: 10.1186/s11671-016-1775-0

The antitumor activity of pristine C
fullerene aqueous solution (C
FAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF
-fenylamino)-1H-pyrrol-2.5-dione (MI-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced by 1.2-dimethylhydrazine (DMH) in rats. The number, size, and location of the tumors were measured, and the pathology was examined. It was found that the number of tumors and total lesion area decreased significantly under the action of C
FAS and MI-1. Because these drugs have different mechanisms of action, their simultaneous administration can potentially increase the effectiveness and significantly reduce the side effects of antitumor therapy.