Positive sentinel node biopsy in breast cancer: is axillary surgery necessary in all cases?

Our retrospective study analyzes various factors to evaluate the risk of invasion of the not sentinel node when the sentinel node biopsy is positive in the infiltrated breast cancers. We compared in single varied then multivaried analysis, various parameters between two groups: positive not sentinel...

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Bibliographic Details
Published in:	Bulletin du cancer Vol. 94; no. 7; p. 700
Main Authors:	Trentini, Frédéric, Saint-Aubert, Bernard, Quenet, François, Gutowski, Marian, Bibeau, Frédéric, Simony-Lafontaine, J, Chateau, Marie-Christine, Pourquier, Didier, Eslimani, Majida, Delfour, Christophe, Gourgou, Sophie, Thezenas, Simon, Rouanet, Philippe
Format:	Journal Article
Language:	French
Published:	France 01-07-2007
Subjects:	Adult Aged Aged, 80 and over Analysis of Variance Axilla Breast Neoplasms - pathology Breast Neoplasms - surgery Coloring Agents Female Humans Lymph Node Excision Lymphatic Metastasis Middle Aged Retrospective Studies Rosaniline Dyes Sentinel Lymph Node Biopsy
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Summary:	Our retrospective study analyzes various factors to evaluate the risk of invasion of the not sentinel node when the sentinel node biopsy is positive in the infiltrated breast cancers. We compared in single varied then multivaried analysis, various parameters between two groups: positive not sentinel nodes and negative not sentinel nodes among 180 cases of positive sentinel node biopsy between 2001 and 2004. At the time of the single varied analysis, seem to be risk factors of non sentinel node involvement: the histopronostic SBRIII rank, positive a HER2neu status, the presence of extracapsulal node extension and infiltration of the sentinel node by a macrometastasis. The tumoral embol, the absence of hormonal receivers, a tumoral size > 10 mm and the number of sentinel node taken appear at the limit of the significativity. In multivaried analysis, SBRIII rank and the presence of an extracapsular node extension remain related to non sentinel node involvement. The histological type, association with a CIS, the size of the sentinel nodes, the number of positive sentinel nodes and the year of surgery are nonsignificant. Additional axillairy clearing out at the time of a positive node sentinel biopsy should be discussed according to different criteria determined by a precise histological analysis.
ISSN:	1769-6917